Natural history of Peritonealcarcinoses


Limited data are available concerning the natural evolution of untreated or palliatively managed PC from non-gynecological origin. The French multicenter EVOCAPE 1 study prospectively followed 370 PC patients, 118 of whom were from colorectal origin. (1) Palliative chemotherapy was given to 46 (39%) of these patients. The median survival of colorectal cancer cases was 5.2 months, a figure resembling other reported outcomes. (2)

Most of these patients already have or will ultimately develop systemic disease. Based on the clinical results of cytoreductive surgery, a small subgroup of patients exists with isolated PC and absent or late occurrence of distant disease. Undoubtedly, genetic profiling techniques will in the near future demonstrate a specific genotype that correlates

  1. Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J/, et al./ Peritoneal carcinomatosis from non-gynecologic malignancies - Results of the EVOCAPE 1 multicentric prospective study/./ /Cancer /2000; *88*: 358-63.
  2. Chu DZJ, Lang NP, Thompson C, Osteen PK, and Westbrook KC. Peritoneal Carcinomatosis in Nongynecologic Malignancy - a Prospective-Study of Prognostic Factors/./ /Cancer /1989; *63*: 364-7.